Paralogous CYP51 Genes of Colletotrichum spp. Mediate Differential Sensitivity to Sterol Demethylation Inhibitors
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چکیده
منابع مشابه
Fluconazole binding and sterol demethylation in three CYP51 isoforms indicate differences in active site topology.
14alpha-Demethylase (CYP51) is a key enzyme in all sterol biosynthetic pathways (animals, fungi, plants, protists, and some bacteria), catalyzing the removal of the C-14 methyl group following cyclization of squalene. Based on mutations found in CYP51 genes from Candida albicans azole-resistant isolates obtained after fluconazole treatment of fungal infections, and using site-directed mutagenes...
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ژورنال
عنوان ژورنال: Phytopathology®
سال: 2020
ISSN: 0031-949X,1943-7684
DOI: 10.1094/phyto-10-19-0385-r